Rgma CLIA Kit for Mouse(Mus musculus) | EIAab.comRgma CLIA Kit for Mouse(Mus musculus)

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Rgma (Gene name),

Repulsive guidance molecule A (Protein name ), RGMA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rgma;

Protein name:

Repulsive guidance molecule A;

Alternative:

RGM domain family member A;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with NEO1, BMP2 and BMP4.

Function:

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor

Protein Attributes:

Sequence length:

454

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

454:

PVLW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q6PCX7

Pfam:

PF06534

SMR:

Q6PCX7

KEGG:

mmu:244058

UniGene:

Mm.333943

Uniprot:

Q6PCX7

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ELISA Kit for Mouse Repulsive guidance molecule A

Cat.:

E3256m

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Packing:

96T

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ELISA Kit for Mouse Repulsive guidance molecule A

Cat.:

E3256h

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96T

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ELISA Kit for Mouse Repulsive guidance molecule A

Cat.:

E3256c

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Packing:

96T

CLIA Kit for Mouse Repulsive guidance molecule A

Cat.:

U3256m

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Packing:

96T

CLIA Kit for Mouse Repulsive guidance molecule A

Cat.:

U3256h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Repulsive guidance molecule A

Cat.:

U3256c

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Packing:

96T

Polyclonal Antibody for Mouse Repulsive guidance molecule A

Cat.:

P3256Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Repulsive guidance molecule A

Cat.:

P3256Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Repulsive guidance molecule A

Protein for Mouse Repulsive guidance molecule A

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Isolation and expression pattern of three mouse homologues of chick Rgm."
Schmidtmer J. , Engelkamp D.
Gene Expr. Patterns4:105-110(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);DEVELOPMENTAL STAGE
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6.
strain: FVB/N.
tissue: Brain.
tissue: Mammary gland.
3.

"Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system."
Niederkofler V. , Salie R. , Sigrist M. , Arber S.
J. Neurosci.24:808-818(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus."
Brinks H. , Conrad S. , Vogt J. , Oldekamp J. , Sierra A. , Deitinghoff L. , Bechmann I. , Alvarez-Bolado G. , Heimrich B. , Monnier P.P. , Mueller B.K. , Skutella T.
J. Neurosci.24:3862-3869(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
5.

"Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor."
Babitt J.L. , Zhang Y. , Samad T.A. , Xia Y. , Tang J. , Campagna J.A. , Schneyer A.L. , Woolf C.J. , Lin H.Y.
J. Biol. Chem.280:29820-29827(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMP2 AND BMP4
6.

"Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC."
Conrad S. , Genth H. , Hofmann F. , Just I. , Skutella T.
J. Biol. Chem.282:16423-16433(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEO1
7.

"Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4."
Xia Y. , Yu P.B. , Sidis Y. , Beppu H. , Bloch K.D. , Schneyer A.L. , Lin H.Y.
J. Biol. Chem.282:18129-18140(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMP2 AND BMP4
8.

"RGMa inhibits neurite outgrowth of neuronal progenitors from murine enteric nervous system via the neogenin receptor in vitro."
Metzger M. , Conrad S. , Skutella T. , Just L.
J. Neurochem.103:2665-2678(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons."
Yoshida J. , Kubo T. , Yamashita T.
Biochem. Biophys. Res. Commun.372:725-729(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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